Strategies for Optimizing Wound Healing and Reducing Scarring
نویسنده
چکیده
The repairing of injured skin tissue is a fundamental biological process essential to the continuity of life. Wound repair is a complex and dynamic process which consists of inflammation, angiogenesis, and tissue formation and remodeling [1,2]. The wound site is deposited with fibrin clots to prevent hemorrhage upon injury. Neutrophils and macrophages infiltrate the wounds and keratinocytes migrate to the wound to recover the barrier function of skin. Granulation tissues are built up by endothelial cells and fibroblasts which migrate to the wounds and deposit extracellular matrices such as collagen. Fibroblasts produce matrix metalloproteinases which remodel the matrices over several months during the final stages of repair.
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